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Minimal biological detail required for faithful brain emulation

Establish the minimal level of biological detail that must be represented to achieve faithful brain emulation, enabling derivation of concrete hardware compute, memory, and interconnect requirements for whole-brain simulations.

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Background

The hardware section underscores that resource estimates for running emulations are radically uncertain because the necessary biophysical fidelity is unknown.

Determining a baseline of required biological detail would anchor engineering targets and help plan infrastructure for scalable emulation.

References

Turning to the demands of running brain emulations, hardware requirements remain radically uncertain, primarily because we don't yet know what level of biological detail is necessary for faithful emulation.

State of Brain Emulation Report 2025 (2510.15745 - Zanichelli et al., 17 Oct 2025) in Hardware requirements