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Essential biological details to preserve in whole-brain reconstructions

Identify which subcellular and other biological details—such as synaptic vesicles and cellular organelles—are essential to preserve in whole-brain structural reconstructions to enable faithful brain emulation.

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Background

The report notes that early whole-brain reconstructions may need to retain richly detailed raw data because the field has not yet determined which biological features are indispensable for emulation fidelity.

A clear list of essential details would allow more efficient data acquisition and storage strategies while safeguarding emulation goals.

References

However, for early whole-brain reconstructions, preserving sufficient raw data to resolve subcellular structures, including synaptic vesicles and cellular organelles, will likely remain essential, as it is not yet clear which biological details are essential for faithful emulation.

— State of Brain Emulation Report 2025 (2510.15745 - Zanichelli et al., 17 Oct 2025) in Data storage and processing: Storage & Bandwidth