Linear-in-dimension T-count synthesis or stronger lower bound
Determine whether arbitrary effectively specified unitaries on a d-dimensional Hilbert space can be synthesized over Clifford+T with a T-count of \widetilde{O}(d), or establish a stronger worst-case lower bound than the known \widetilde{\Omega}(d) bound at constant accuracy.
References
The known lower bound at constant accuracy remains \Omega(d), leaving a multiplicative gap of \widetilde O(d{1/4}). Determining whether arbitrary unitaries can be synthesized with \widetilde O(d) T gates, or establishing a stronger lower bound, remains the central open problem.
At $n$ qubits the resource landscape is less settled, and the contrast matters for what follows, since the pipelines used in practice are multi-qubit ones. General lower bounds on non-Clifford resources are due to Beverland, Campbell, Howard, and Kliuchnikov and to Low, Kliuchnikov, and Schaeffer, recent upper-bound improvements to Tan, and the gap between the two remains open.