Height inequality for unions of structured submatrices
Determine whether, for subsets I_1 J_1,\ldots,I_s J_s satisfying condition (19) of Theorem 3.8 and T=\bigcup_{\alpha=1}^s I_\alpha J_\alpha, the inequality \operatorname{height}(I_T)\geq\sum_{\alpha=1}^s\operatorname{height}(I_{I_\alpha J_\alpha}) holds, thereby potentially providing an alternative proof of Theorem 3.8 via the general height criterion.
References
This raises the following question. Suppose $I_1 J_1, \ldots, I_s J_s$ satisfies condition eq:condition_dep_Asche of Theorem \ref{thm:dependent_Asche}, and let $T= \bigcup_{\alpha=1}s I_\alpha J_\alpha$. Is it true that
\height(I_T) \ge \sum_{\alpha=1}s \height(I_{I_\alpha J_\alpha}) \ ?
eq:condition_dep_Asche:
At least for height optimization, it seems possible to characterize the class of MSAs with gaps where the gaps-as-symbols approach yields an optimal solution, and not just an upper bound. Such characterization should be possible through forbidding local sub-optimal alignments like A- and -A. This raises several natural questions: What is the exact form of the characterization?