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Functional role of restricted EGL3 movement

Determine the functional role of restricted intercellular movement of ENHANCER OF GLABRA3 (EGL3) relative to GLABRA3 (GL3) in Arabidopsis root epidermal patterning.

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Background

GL3 and EGL3 are bHLH factors that can move between epidermal cells; EGL3 has been reported to move more restrictively than GL3. Movement of these proteins is hypothesized to be diffusive, and gradients shaped by WER/MYB23-mediated repression are thought to influence intercellular transport and complex formation.

The authors note it is unknown what functional role, if any, this restriction in EGL3 movement serves in patterning. Their later modelling suggests restricted EGL3 movement is essential for correct patterning, but the explicit open statement indicates the biological role of this restriction remains to be clarified and experimentally established.

References

It is not known what, if any, functional role the restriction of EGL3 movement has in epidermal patterning.

— A theoretical investigation provides an integrated understanding of the complex regulatory network controlling Arabidopsis root hair patterning (2412.11338 - Mills et al., 15 Dec 2024) in Section 1. Introduction