Feasibility of a Martian biosphere
Determine whether Mars can support a sustained biosphere capable of supporting large numbers of people, considering constraints such as present-day temperature, water availability, soil chemistry (e.g., perchlorates and salts), and atmospheric composition, and quantify the environmental modifications required to make this possible.
References
Whether Mars can support a biosphere is unknown.
Against these agents on the scale of a meter thick regolith (or other solid material) layer gives enough shielding, and the millimetre thin mineral cover is not enough here. However, in theory, highly adapted organisms (Olsson-Francis and Cockell, 2009) could repair their internal radiation-driven damages in the active phase, the question is: could an organism provide enough regular repair using the short periods useful for metabolism and related living activities under the harsh conditions. Based on our current knowledge this cannot be properly answered (Michalski et al., 2018), although it cannot be excluded; however, it remains a highly theoretical question.