Existence of a general-purpose physical machine for molecule output
Investigate whether a general-purpose physical machine capable of outputting any buildable molecule exists; if such a machine exists, formalize a notion of Kolmogorov complexity for physical molecules, and if not, establish the implications for defining Kolmogorov complexity for physical molecules.
References
Because we do not know of a general-purpose machine that can output any physical molecule (rather than a description of the molecule) the Kolmogorov complexity of a physical molecule is not definable, only the complexity of the molecule's mathematical representation is well-defined.
                — Assembly Theory and its Relationship with Computational Complexity
                
                (2406.12176 - Kempes et al., 18 Jun 2024) in Section “Kolmogorov-Chaitin Complexity versus Assembly Index”