Estimate patient-specific stress model parameters from resting data

Develop a method to estimate parameters of a patient-specific coronary stress dynamics model—governing changes in downstream coronary vasculature during stress—using only resting-state clinical measurements such as fractional flow reserve, thereby enabling calibration without stress data.

Background

The paper uses a deliberately simple stress model to avoid confounding comparisons across patients and because patient-specific stress parameters are hard to infer without stress measurements.

The authors explicitly state the challenge of calibrating a more detailed, patient-specific stress dynamics model using only resting data, identifying this as an unresolved methodological problem.