Dice Question Streamline Icon: https://streamlinehq.com

Determine the etiology of Long COVID and ME/CFS

Determine the biological etiology and causal mechanisms underlying Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), as the root causes remain undetermined and currently prevent the authors from making conclusive claims in the analysis of Long COVID data.

Information Square Streamline Icon: https://streamlinehq.com

Background

The paper evaluates digital biomarkers (UpTime and HUA) for assessing disease severity in ME/CFS and Long COVID and finds both measures distinguish patients from healthy controls. However, the authors emphasize that the fundamental causes of these conditions are not established.

This unresolved etiology limits the interpretation of Long COVID analyses and suggests that understanding pathophysiology is essential for advancing objective assessment and treatment strategies.

References

It is important to note that the root cause of Long COVID and ME/CFS is yet to be determined, and these two diseases might respond differently to the same treatment. Given the uncertainty surrounding the etiology of these conditions, we cannot make conclusive claims in the analysis of the Long COVID data.

— System and Method to Determine ME/CFS and Long COVID Disease Severity Using a Wearable Sensor (2404.04345 - Sun et al., 5 Apr 2024) in Discussion, Section 5