Additional data for distinguishing behavioral multiscale and standard SEIR models

Identify which additional data sets are needed to determine whether population-level disease trajectories are better described by a standard SEIR-like model without explicit behavior change or by a multiscale behavioral model.

Background

The paper notes that epidemic curves generated by the symptom-score-driven multiscale model can closely resemble those of a standard SEIR model, creating an identifiability problem: population-level disease trajectories alone may not reveal whether illness-driven behavioral change is present.

The authors specifically point to symptom-severity and corresponding behavioral-survey data as possible supplementary observations beyond the within-host viral-load and population-level case-count data commonly used for fitting multiscale models. Determining the informative value of such additional, potentially sparse data is left unresolved.

References

Furthermore, its important to ask which additional data sets need to be observed to know if population-level disease trajectories are better described by a standard SEIR-like model that does not explicitly account for behavior change or by a multi-scale behavioral model.