Bifurcation detection in EMT morphodynamics via POD entropy analysis

Ascertain, using proper orthogonal decomposition and mode-entropy analysis, whether a bifurcation occurs in the morphodynamics of EGF-induced EMT by obtaining adequate snapshots before and after the putative bifurcation and performing the analysis.

Background

The authors observe trajectory differences in the modal space during induction and reversal of EMT reminiscent of hysteresis, but caution against inferring bifurcation without appropriate analysis.

They state that POD can detect bifurcation via entropy changes but were unable to conduct this analysis due to insufficient temporal sampling, leaving the presence or absence of bifurcation unresolved.