Translatability of sCT clinical acceptance criteria across anatomies

Determine whether existing synthetic CT clinical acceptance criteria—such as a photon gamma pass rate greater than 98% using the 2 mm/2% criterion or a dose–volume histogram difference below 2%—established for breast, head-and-neck, and thorax translate to other anatomical regions relevant to SynthRAD2023, including brain and pelvis, or establish appropriate region-specific criteria if they do not.

Background

SynthRAD2023 assessed sCT quality using dose-related metrics that are clinically pertinent, yet there is no broad consensus on acceptance criteria across all anatomical regions.

Published criteria (e.g., photon gamma pass rate ≥98% at 2%/2 mm; DVH difference <2%) were proposed for specific sites (breast, head-and-neck, thorax). The authors explicitly note it is unclear whether these criteria apply to other regions, such as brain and pelvis, creating a concrete clinical evaluation gap.