Atiyah–Floer conjecture: relate instanton and Lagrangian Floer homologies
Prove the Atiyah–Floer conjecture by establishing that, for any Heegaard splitting of a closed 3-manifold Y along a surface Σ, the instanton Floer homology of Y is isomorphic to the Lagrangian Floer homology of the pair of Lagrangian submanifolds in the moduli space of flat connections over Σ determined by the two handlebodies of the splitting.
References
these are related to Lagrangian Floer theory via the Atiyah-Floer conjecture , which, given a Heegaard splitting of $Y$ as above, relates the instanton Floer homology of $Y$ to the Lagrangian Floer homology of a pair of Lagrangian submanifolds in a moduli space of flat connections over the surface $\Sigma$. See e.g.\ the work of Salamon-Wehrheim and Daemi-Fukaya-Lipyanskiy for progress towards the conjecture.