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Generic temperature response in biochemical networks

Ascertain whether large biochemical networks exhibit a generic response to temperature changes across different architectures and conditions.

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Background

Prior empirical work indicates that complex biological systems often do not display the Arrhenius form typical of single reactions. In developmental systems, measured rates frequently show concave temperature responses in Arrhenius plots.

Given the complexity and nonlinearity of biochemical networks, the question of a universal or generic network-level temperature response is central to building theoretical frameworks applicable to systems like immune responses and ecosystems.

References

However, a fundamental theoretical understanding of this striking observation is missing and it is an open question if such networks show a generic response to temperature changes.

The generic temperature response of large biochemical networks (2403.17202 - Voits et al., 25 Mar 2024) in Section 1, Introduction