Analytic solution for the perturbative MLE equation in the near-circular limit
Derive an analytic solution for the maximum-likelihood estimate of the field direction ψ̂ defined in the near-circular perturbative limit by the nonlinear trigonometric equation A cos(ψ̂) − B sin(ψ̂) = C sin(2ψ̂), where A = (1/N) ∑i sin(νi), B = (1/N) ∑i cos(νi), and C = [I2(κ)]/[κ I0(κ) cosh(2μ0)], which arises from the elliptical-cell electrophoretic sensor-redistribution model.
References
We do not have an analytic solution to this, but we have solved this numerically and find consistent answers with our numerical optimization to find the maximum likelihood estimator.
— Cell shape and orientation control galvanotactic accuracy
(2407.17420 - Nwogbaga et al., 24 Jul 2024) in Appendix: Perturbation calculations for MLE and Fisher information for nearly circular cells (Appendix A, after Eq. (MLE_perturbation))