Evaluating the Impact of a Specialized LLM on Physician Experience in Clinical Decision Support: A Comparison of Ask Avo and ChatGPT-4

Abstract: The use of LLMs to augment clinical decision support systems is a topic with rapidly growing interest, but current shortcomings such as hallucinations and lack of clear source citations make them unreliable for use in the clinical environment. This study evaluates Ask Avo, an LLM-derived software by AvoMD that incorporates a proprietary LLM Augmented Retrieval (LMAR) system, in-built visual citation cues, and prompt engineering designed for interactions with physicians, against ChatGPT-4 in end-user experience for physicians in a simulated clinical scenario environment. Eight clinical questions derived from medical guideline documents in various specialties were prompted to both models by 62 study participants, with each response rated on trustworthiness, actionability, relevancy, comprehensiveness, and friendly format from 1 to 5. Ask Avo significantly outperformed ChatGPT-4 in all criteria: trustworthiness (4.52 vs. 3.34, p<0.001), actionability (4.41 vs. 3.19, p<0.001), relevancy (4.55 vs. 3.49, p<0.001), comprehensiveness (4.50 vs. 3.37, p<0.001), and friendly format (4.52 vs. 3.60, p<0.001). Our findings suggest that specialized LLMs designed with the needs of clinicians in mind can offer substantial improvements in user experience over general-purpose LLMs. Ask Avo's evidence-based approach tailored to clinician needs shows promise in the adoption of LLM-augmented clinical decision support software.