Scalable Bayesian Inference for Population Markov Jump Processes

Abstract: Bayesian inference for Markov jump processes (MJPs) where available observations relate to either system states or jumps typically relies on data-augmentation Markov Chain Monte Carlo. State-of-the-art developments involve representing MJP paths with auxiliary candidate jump times that are later thinned. However, these algorithms are i) unfeasible in situations involving large or infinite capacity systems and ii) not amenable for all observation types. In this paper we establish and present a general data-augmentation framework for population MJPs based on uniformized representations of the underlying non-stationary jump processes. This leads to multiple novel MCMC samplers which enable exact (in the Monte Carlo sense) inference tasks for model parameters. We show that proposed samplers outperform existing popular approaches, and offer substantial efficiency gains in applications to partially observed stochastic epidemics, immigration processes and predator-prey dynamical systems.