TriPAH: Imbalance-Aware Tri-Prompt Affinity Hashing for Cross-Modal Medical Retrieval

Abstract: In the era of big medical data, efficient cross-modal retrieval is pivotal for evidence-based diagnosis and large-scale case management. Cross-modal medical hashing retrieval aims to enable efficient image-text search and support downstream tasks such as case-based reasoning and decision support by learning compact, semantically aligned binary codes. However, current methods suffer from semantic fragmentation due to noisy clinical language, long-tailed labels, and brittle quantization that weakens alignment. We propose TriPAH, a Tri-Prompt Affinity Hashing framework. TriPAH synthesizes ontology-grounded, patient-level prompts conditioned on normalized clinical cues to yield low-noise textual representations for initial alignment. A lightweight prompt-token mixer performs hierarchical, multi-granularity alignment and produces quantization-ready features under an asymmetric multi-task objective coupling multi-positive contrastive alignment, imbalance-aware classification, and progressive quantization regularization. A patient-level consistency module further stabilizes codes across complementary views. Extensive experiments on three public datasets demonstrate that TriPAH significantly outperforms state-of-the-art methods.