PMC-InterCPT: Rethinking Biomedical Interleaved Data for Multimodal Continued Pretraining

Abstract: Large-scale biomedical image-text datasets extracted from scientific literature provide valuable resources for medical multimodal model training. These datasets are commonly organized as image-caption pairs; however, figure captions are often short, context-dependent, and only partially informative without the surrounding article text. At the same time, large-scale automatic extraction introduces structural noise such as missing captions, residual markup, duplicated context, and incoherent multi-paragraph figure descriptions. We revisit data construction for medical multimodal continued pretraining (CPT) and present PMC-InterCPT, a context-grounded biomedical interleaved corpus that incorporates figure-referencing body text in addition to captions. Our pipeline recovers missing captions, cleans caption and context text, reconstructs coherent interleaved image-text samples, and applies LLM-supervised medical relevance and quality classifiers to filter noisy records. We further reveal strong modality imbalance in the resulting corpus and introduce a four-bucket evidence taxonomy for modality-aware resampling. Through CPT followed by supervised fine-tuning (SFT) on Qwen3.5-4B-Base, PMC-InterCPT effectively improves medical and general multimodal performance while using fewer CPT tokens than the raw source pool. The experimental results also illustrate the complementarity between the data quality and modality for medical multimodal CPT.