Evi-Steer: Learning to Steer Biomedical Vision-Language Models through Efficient and Generalizable Evidential Tuning

Abstract: Parameter-efficient adaptation of vision-language foundation models is crucial for precise multimodal understanding of biomedical images, yet existing methods remain deterministic and often struggle under domain shift or ambiguous image-text alignment. This limitation is particularly critical in the clinic, where models should remain robust in low-data regimes and domain shifts. We present Evi-Steer, an evidential cross-modal low-dimensional steering framework for BiomedCLIP that enables uncertainty-aware parameter-efficient fine-tuning while updating only 0.11% of total model parameters. Our approach performs lightweight low-dimensional token updates in both vision and text encoders while simultaneously estimating epistemic uncertainty. These uncertainty estimates update gate residuals, allowing the model to adapt conservatively when evidence is weak. Furthermore, we introduce cross-modal confidence fusion based on Dempster-Shafer theory, enabling visual adaptation to be conditioned on textual confidence and suppressing conflicting or uncertain cross-modal updates. We conduct a comprehensive evaluation on 15 biomedical imaging datasets spanning 8 organs and 8 imaging modalities under few-shot learning and domain generalization settings. Evi-Steer consistently outperforms state-of-the-art methods under few-shot learning and domain shift settings, demonstrating a practical and robust pathway for deploying vision-LLMs in real-world clinical settings. Code is available at https://github.com/HealthX-Lab/Evi-Steer.