PROMETHEUS: Automating Deep Causal Research Integrating Text, Data and Models

Abstract: LLMs can extract local causal claims from text, but those claims become more useful when organized as persistent, navigable world models rather than as flat summaries. We introduce PROMETHEUS, a framework that turns retrieved literature, filings, reviews, reports, agent traces, source data, code, simulations, and scientific models into causal atlases: sheaf-like families of local causal predictive-state models over an explicit cover of a research substrate. Each local region contains causal episodes, structured claim tables, predictive tests, support statistics, and provenance; restriction maps compare overlapping regions; gluing diagnostics expose agreement, drift, contradiction, and underdetermination. The resulting Topos World Model is not a single universal graph. It is a research instrument for navigating what a corpus says, where it says it, how strongly it is supported, and where local claims fail to assemble into a coherent global view. Three literature-atlas case studies -- ocean-temperature impacts on marine populations, GLP-1 weight-loss evidence, and resveratrol/red-wine health-benefit claims -- illustrate deep causal research from text with explicit locality, evidence, persistent state, and gluing tension. Four grounded-counterfactual case studies -- a Nature Climate Change microplastics forcing paper, an Indus Valley hydrology paper with VIC-derived figure data and model code, the canonical Sachs protein-signaling study with single-cell perturbation data, and a Nature singing-mouse study with MAPseq projection matrices -- show a stronger mode: when a paper ships source data, simulation outputs, or code, PROMETHEUS can evaluate a counterfactual against that scientific substrate and then rebuild the sheaf world model around the