Abstract: The discovery of hidden-charm pentaquarks and open-flavor tetraquarks motivates the search for even more exotic hadron configurations. In this work, we investigate genuinely exotic molecular pentaquark candidates comprising five different flavors, focusing on the Ξb<sup>(′,∗)</sup>Dˉ<sup>(∗) and Ξc<sup>(′,∗)</sup>B<sup>(∗) systems. Employing the one-boson-exchange model with the S-D wave mixing and coupled-channel dynamics, we identify the most promising molecular pentaquark candidates comprising five different flavors. These include the ΞbDˉ, Ξb<sup>′</sup>Dˉ, ΞcB, and Ξc<sup>′</sup>B states with I(J<sup>P)=0(1/2<sup>−), the ΞbDˉ<sup>∗, Ξb<sup>′</sup>Dˉ<sup>∗, ΞcB<sup>∗, and Ξc<sup>′</sup>B<sup>∗ states with I(J<sup>P)=0(1/2<sup>−,3/2<sup>−), the Ξb<sup>∗</sup>Dˉ and Ξc<sup>∗</sup>B states with I(J<sup>P)=0(3/2<sup>−), as well as the Ξb<sup>∗</sup>Dˉ<sup>∗ and Ξc<sup>∗</sup>B<sup>∗ states with I(J<sup>P)=0(1/2<sup>−,3/2<sup>−,5/2<sup>−). Importantly, these loosely bound states exhibit pronounced spin splittings across different total angular momentum configurations after incorporating the spin-dependent interactions or the channel couplings. In addition, we identify several possible isovector molecular pentaquark candidates within the Ξb<sup>(′,∗)</sup>Dˉ<sup>(∗) and Ξc<sup>(′,∗)</sup>B<sup>(∗) systems. Our predictions provide clear targets for experimental searches at facilities such as LHCb and Belle II, where the unique five-flavor quark configuration offers a distinctive experimental signature.