Composed Vision-Language Retrieval for Skin Cancer Case Search via Joint Alignment of Global and Local Representations

Abstract: Medical image retrieval aims to identify clinically relevant lesion cases to support diagnostic decision making, education, and quality control. In practice, retrieval queries often combine a reference lesion image with textual descriptors such as dermoscopic features. We study composed vision-language retrieval for skin cancer, where each query consists of an image to text pair and the database contains biopsy-confirmed, multi-class disease cases. We propose a transformer based framework that learns hierarchical composed query representations and performs joint global-local alignment between queries and candidate images. Local alignment aggregates discriminative regions via multiple spatial attention masks, while global alignment provides holistic semantic supervision. The final similarity is computed through a convex, domain-informed weighting that emphasizes clinically salient local evidence while preserving global consistency. Experiments on the public Derm7pt dataset demonstrate consistent improvements over state-of-the-art methods. The proposed framework enables efficient access to relevant medical records and supports practical clinical deployment.