Template-free precision synthesis of biphilic microdome arrays

Abstract: Biphilic microdome arrays are ubiquitous in nature, but their synthetic counterparts have been scarce. To bridge that gap, we leverage condensed droplet polymerization (CDP) to enable their template-free synthesis. During CDP, monomer droplets serve as microreactors for free-radical polymerization. The droplet diameter is monitored in real time. To enable the precise prediction of the convex geometric parameters, we develop a theoretical framework that integrates geometric arguments, scaling analysis, and kinetic theories. The model accurately predicts the dimensions of the as-synthesized microdome arrays, pointing to unprecedented precision in the synthesis of such topography. To illustrate its impact, the methodology is used to enable biphilic microdomes with targeted dimensions, for the reduction of surface colonization by a biofilm-forming pathogen, Pseudomonas aeruginosa. Importantly, the reduction is achieved with a moderately hydrophobic surface that has been considered prone to fouling, pointing to a fresh material design strategy and broadened palette of synthetic surfaces.