NeuroPal: A Clinically-Informed Multimodal LLM Assistant for Mental Health Combining Sleep Chronotherapy, Cognitive Behavioral Reframing, and Adaptive Phytochemical Intervention (2505.06640v1)

Abstract: Due to time constraints, mental health professionals in China are unable to offer patients prolonged talk therapy, leaving a gap in care for patients with psychological disorders, including aberrant sleep and eating patterns, maladaptive explanatory styles, and gastrointestinal dysfunction. To bridge this gap in care and address these problems in a large-scale manner, we built NeuroPal, a LLM-assistant that provides scalable, evidence-based interventions with three clinically validated modules: (1) a sleep chronotherapy planner to output personalized circadian rhythm correction protocols, (2) a cognitive-behavioral reframing engine grounded in CBT and humanistic principles to shift negative attributional biases, and (3) a biochemical regulation advisor to output phytotherapy formulations to regulate sleep-metabolism-gut-axis imbalances. In collaboration with Peking Union Medical College Hospital and Xiangya Hospital Central South University, we ran an RCT protocol with 513 participants with mood/anxiety disorders and showed statistically significant improvements towards primary endpoints (> p<.01). Experiment shows 37.2% drop in the Pittsburgh Sleep Quality Index (PSQI), 28.6% rise in positive affective word usages (LIWC analysis), and 23.4% improvement in patient-reported digestive comfort. The assistant also reached 89.1% adherence rates, significantly higher than the human-guided therapy intervention (72.3%) in matched controls. Our results indicate that an LLM-driven multimodal intervention is able to successfully bridge time-constrained clinical practice while preserving therapeutic effectiveness. For next steps, we plan to explore longitudinal outcome tracking and FDA/CFDA certification routes.