Causal Inference under Interference: Regression Adjustment and Optimality

Abstract: In randomized controlled trials without interference, regression adjustment is widely used to enhance the efficiency of treatment effect estimation. This paper extends this efficiency principle to settings with network interference, where a unit's response may depend on the treatments assigned to its neighbors in a network. We make three key contributions: (1) we establish a central limit theorem for a linear regression-adjusted estimator and prove its optimality in achieving the smallest asymptotic variance within a class of linear adjustments; (2) we develop a novel, consistent estimator for the asymptotic variance of this linear estimator; and (3) we propose a nonparametric estimator that integrates kernel smoothing and trimming techniques, demonstrating its asymptotic normality and its optimality in minimizing asymptotic variance within a broader class of nonlinear adjustments. Extensive simulations validate the superior performance of our estimators, and a real-world data application illustrates their practical utility. Our findings underscore the power of regression-based methods and reveal the potential of kernel-and-trimming-based approaches for further enhancing efficiency under network interference.