Papers
Topics
Authors
Recent
Search
2000 character limit reached

Gradient-based optimization for variational empirical Bayes multiple regression

Published 21 Nov 2024 in stat.ME, stat.CO, and stat.ML | (2411.14570v1)

Abstract: Variational empirical Bayes (VEB) methods provide a practically attractive approach to fitting large, sparse, multiple regression models. These methods usually use coordinate ascent to optimize the variational objective function, an approach known as coordinate ascent variational inference (CAVI). Here we propose alternative optimization approaches based on gradient-based (quasi-Newton) methods, which we call gradient-based variational inference (GradVI). GradVI exploits a recent result from Kim et. al. [arXiv:2208.10910] which writes the VEB regression objective function as a penalized regression. Unfortunately the penalty function is not available in closed form, and we present and compare two approaches to dealing with this problem. In simple situations where CAVI performs well, we show that GradVI produces similar predictive performance, and GradVI converges in fewer iterations when the predictors are highly correlated. Furthermore, unlike CAVI, the key computations in GradVI are simple matrix-vector products, and so GradVI is much faster than CAVI in settings where the design matrix admits fast matrix-vector products (e.g., as we show here, trendfiltering applications) and lends itself to parallelized implementations in ways that CAVI does not. GradVI is also very flexible, and could exploit automatic differentiation to easily implement different prior families. Our methods are implemented in an open-source Python software, GradVI (available from https://github.com/stephenslab/gradvi ).

Summary

  • The paper introduces GradVI as a gradient-based alternative to CAVI, offering improved convergence and computational efficiency in sparse multiple regression.
  • It reformulates Bayesian sparse regression as penalized linear regression by numerically inverting the posterior mean or using compound penalty reparametrization.
  • Practical experiments demonstrate that GradVI leverages quasi-Newton methods and automatic differentiation to handle highly correlated predictors in large-scale data.

Gradient-Based Optimization for Variational Empirical Bayes Multiple Regression

The paper presented by Banerjee et al. discusses a novel approach to fitting large, sparse multiple regression models using variational empirical Bayes (VEB) methods. Traditional methods in this domain have relied heavily on coordinate ascent algorithms, such as coordinate ascent variational inference (CAVI). This paper introduces an alternative approach, namely gradient-based variational inference (GradVI), which leverages gradient-based optimization techniques, specifically quasi-Newton methods, to optimize the variational objective function.

Overview of Methods

The research revisits the classical multiple linear regression problem that is central to many scientific and engineering applications. In scenarios with a large number of predictor variables, inducing sparsity in the regression coefficients is crucial for avoiding overfitting. The traditional CAVI approach, while effective in some scenarios, particularly in simpler models, faces convergence issues and inefficiencies when dealing with highly correlated predictors or when the structure of the design matrix could be exploited for faster computations.

GradVI harnesses recent theoretical advancements that allow the variational inference problem to be recast as a penalized linear regression (PLR). This reframing leverages the relationship between Bayesian sparse regression under a normal means model and PLR by interpreting the posterior mean within the regression context. However, the intrinsic penalty function is not plainly accessible, prompting two distinct strategies in this work to navigate this limitation: numerical inversion of the posterior mean operator and reparametrization via compound penalty functions.

Numerical Results and Implications

The paper provides detailed numerical experiments demonstrating that GradVI achieves comparable predictive performance to CAVI while offering significant computational advantages. In tests where the predictors were highly correlated, GradVI displayed faster convergence and enhanced flexibility by exploiting automatic differentiation, which facilitates implementing diverse prior families.

Notably, the research shows that in settings where the design matrix allows efficient matrix-vector products (such as in trend filtering applications), GradVI is markedly faster. The authors argue convincingly that these computational efficiencies make GradVI a more robust and scalable tool for tackling large-scale problems prevalent in modern data-rich environments.

Practicality and Scope of GradVI

The open-source Python software implementation of GradVI provides a practical resource for other researchers and practitioners looking to apply these methods in various applications. The work makes compelling arguments for the versatility of GradVI, particularly regarding model initialization strategies that reduce sensitivity and improve accuracy compared to CAVI.

Future Directions

The flexibility of GradVI suggests potential for application beyond multiple regression to more complex Bayesian models. Future research might explore the integration of automatic differentiation tools, which could further streamline the implementation process for different priors and optimize computational performance. Additionally, there remains the vibrant possibility of exploring alternative gradient-based algorithms, such as the full Newton's method, to further enhance convergence speeds.

GradVI stands as a significant advancement in the field of Bayesian sparse linear regression, providing a balance of flexibility, computational efficiency, and ease of implementation that renders it a promising tool for researchers and practitioners dealing with high-dimensional data.

Overall, this work by Banerjee et al. presents a substantial contribution to the field, paving the way for more efficient handling of complex regression models in both theoretical and practical frameworks.

Paper to Video (Beta)

No one has generated a video about this paper yet.

Whiteboard

No one has generated a whiteboard explanation for this paper yet.

Open Problems

We haven't generated a list of open problems mentioned in this paper yet.

Continue Learning

We haven't generated follow-up questions for this paper yet.

Collections

Sign up for free to add this paper to one or more collections.

Tweets

Sign up for free to view the 2 tweets with 3 likes about this paper.