The Literature Review Network: An Explainable Artificial Intelligence for Systematic Literature Reviews, Meta-analyses, and Method Development

Abstract: Systematic literature reviews are the highest quality of evidence in research. However, the review process is hindered by significant resource and data constraints. The Literature Review Network (LRN) is the first of its kind explainable AI platform adhering to PRISMA 2020 standards, designed to automate the entire literature review process. LRN was evaluated in the domain of surgical glove practices using 3 search strings developed by experts to query PubMed. A non-expert trained all LRN models. Performance was benchmarked against an expert manual review. Explainability and performance metrics assessed LRN's ability to replicate the experts' review. Concordance was measured with the Jaccard index and confusion matrices. Researchers were blinded to the other's results until study completion. Overlapping studies were integrated into an LRN-generated systematic review. LRN models demonstrated superior classification accuracy without expert training, achieving 84.78% and 85.71% accuracy. The highest performance model achieved high interrater reliability (k = 0.4953) and explainability metrics, linking 'reduce', 'accident', and 'sharp' with 'double-gloving'. Another LRN model covered 91.51% of the relevant literature despite diverging from the non-expert's judgments (k = 0.2174), with the terms 'latex', 'double' (gloves), and 'indication'. LRN outperformed the manual review (19,920 minutes over 11 months), reducing the entire process to 288.6 minutes over 5 days. This study demonstrates that explainable AI does not require expert training to successfully conduct PRISMA-compliant systematic literature reviews like an expert. LRN summarized the results of surgical glove studies and identified themes that were nearly identical to the clinical researchers' findings. Explainable AI can accurately expedite our understanding of clinical practices, potentially revolutionizing healthcare research.