Symmetry engineering in 2D bioelectronics facilitating augmented biosensing interfaces

Abstract: Symmetry lies at the heart of 2D bioelectronics, determining material properties at the fundamental level. Breaking the symmetry allows emergent functionalities and effects. However, symmetry modulation in 2D bioelectronics and the resultant applications have been largely overlooked. Here we devise an oxidized architectural MXene, referred as OXene, that couples orbit symmetric breaking with inverse symmetric breaking to entitle the optimized interfacial impedance and Schottky-induced piezoelectric effects. The resulting OXene validates applications ranging from microelectrode arrays, gait analysis, active transistor matrix, and wireless signaling transmission, which enables highly-fidelity signal transmission and reconfigurable logic gates. Further OXene interfaces are investigated in both rodent and porcine myocardium, featuring high-quality and spatiotemporally resolved physiological recordings, while accurate differentiated predictions, enabled via various machine learning pipelines.