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X-ray phase and dark-field computed tomography without optical elements (2310.09496v2)

Published 14 Oct 2023 in physics.med-ph, eess.IV, and physics.optics

Abstract: X-ray diffusive dark-field imaging, which allows spatially unresolved microstructure to be mapped across a sample, is an increasingly popular tool in an array of settings. Here, we present a new algorithm for phase and dark-field computed tomography based on the x-ray Fokker-Planck equation. Needing only a coherent x-ray source, sample, and detector, our propagation-based algorithm can map the sample density and dark-field/diffusion properties of the sample in 3D. Importantly, incorporating dark-field information in the density reconstruction process enables a higher spatial resolution reconstruction than possible with previous propagation-based approaches. Two sample exposures at each projection angle are sufficient for the successful reconstruction of both the sample density and dark-field Fokker-Planck diffusion coefficients. We anticipate that the proposed algorithm may be of benefit in biomedical imaging and industrial settings.

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References (62)
  1. M. Endrizzi, “X-ray phase-contrast imaging,” \JournalTitleNucl. Inst. Meth. Phys. Res. A 878, 88–98 (2018).
  2. F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, C. Brönnimann, C. Grünzweig, and C. David, “Hard-x-ray dark-field imaging using a grating interferometer,” \JournalTitleNat. Mater. 7, 134–137 (2008).
  3. Z. Wang, K. Kang, Z. Huang, and Z. Chen, “Quantitative grating-based x-ray dark-field computed tomography,” \JournalTitleAppl. Phys. Lett. 95, 094105 (2009).
  4. M. Bech, O. Bunk, T. Donath, R. Feidenhans’l, C. David, and F. Pfeiffer, “Quantitative x-ray dark-field computed tomography,” \JournalTitlePhys. Med. Biol. 55(18), 5529 (2010).
  5. F. Prade, K. Fischer, P. Meyer, J. Mohr, and F. Pfeiffer, “Time resolved X-ray Dark-Field Tomography Revealing Water Transport in a Fresh Cement Sample,” \JournalTitleSci. Rep. 6, 29108 (2016).
  6. R. Burkhardt, T. Gora, A. A. Fingerle, A. P. Sauter, F. Meurer, F. T. Gassert, S. Dobiasch, D. Schilling, A. Feuchtinger, A. K. Walch, G. Multhoff, J. Herzen, P. B. Noël, E. J. Rummeny, S. E. Combs, T. E. Schmid, F. Pfeiffer, and J. J. Wilkens, “In-vivo X-ray dark-field computed tomography for the detection of radiation-induced lung damage in mice,” \JournalTitlePhys. Imaging Radiat. Oncol. 20, 11–16 (2021).
  7. B. K. Blykers, C. Organista, M. N. Boone, M. Kagias, F. Marone, M. Stampanoni, T. Bultreys, V. Cnudde, and J. Aelterman, “Tunable x-ray dark-field imaging for sub-resolution feature size quantification in porous media,” \JournalTitleSci. Rep. 11(1), 18446 (2021).
  8. K. Willer, A. A. Fingerle, W. Noichl, F. De Marco, M. Frank, T. Urban, R. Schick, A. Gustschin, B. Gleich, J. Herzen, T. Koehler, A. Yaroshenko, T. Pralow, G. S. Zimmermann, B. Renger, A. P. Sauter, D. Pfeiffer, M. R. Makowski, E. J. Rummeny, P. A. Grenier, and F. Pfeiffer, “X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study,” \JournalTitleLancet Digit 3(111), e733–e744 (2021).
  9. F. T. Gassert, T. Urban, A. Kufner, M. Frank, G. C. Feuerriegel, T. Baum, M. R. Makowski, C. Braun, D. Pfeiffer, B. J. Schwaiger, F. Pfeiffer, and A. S. Gersing, “Dark-field X-ray imaging for the assessment of osteoporosis in human lumbar spine specimens,” \JournalTitleFront. Physiol. 14, 1217007 (2023).
  10. M. Viermetz, N. Gustschin, C. Schmid, J. Haeusele, B. Gleich, B. Renger, T. Koehler, and F. Pfeiffer, “Initial characterization of dark-field CT on a clinical gantry,” \JournalTitleIEEE Trans. Med. Imaging 42(4), 1035–1045 (2022).
  11. E. Pagot, P. Cloetens, S. Fiedler, A. Bravin, P. Coan, J. Baruchel, J. Härtwig, and W. Thomlinson, “A method to extract quantitative information in analyzer-based x-ray phase contrast imaging,” \JournalTitleAppl. Phys. Lett. 82(20), 3421–3423 (2003).
  12. W. Yashiro, Y. Terui, K. Kawabata, and A. Momose, “On the origin of visibility contrast in x-ray Talbot interferometry,” \JournalTitleOpt. Express 18(16), 16890–16901 (2010).
  13. F. Schaff, F. Prade, Y. Sharma, M. Bech, and F. Pfeiffer, “Non-iterative Directional Dark-field Tomography,” \JournalTitleSci. Rep. 7, 3307 (2017).
  14. K. S. Morgan, D. M. Paganin, and K. W. Siu, “X-ray phase imaging with a paper analyzer,” \JournalTitleAppl. Phys. Lett. 100(12), 124102 (2012).
  15. S. Berujon, H. Wang, and K. Sawhney, “X-ray multimodal imaging using a random-phase object,” \JournalTitlePhys. Rev. A 86, 063813 (2012).
  16. H. Wang, Y. Kashyap, and K. Sawhney, “Quantitative X-ray dark-field and phase tomography using single directional speckle scanning technique,” \JournalTitleAppl. Phys. Lett. 108(12), 124102 (2016).
  17. M. C. Zdora, “State of the Art of X-ray Soeckle-Based Phase-Contrast and Dark-Field Imaging,” \JournalTitleJ. Imaging 4(5), 60 (2018).
  18. M.-C. Zdora, P. Thibault, H. Deyhle, J. Vila-Comamala, C. Rau, and I. Zanette, “Tunable X-ray speckle-based phase-contrast and dark-field imaging using the unified modulated pattern analysis approach,” \JournalTitleJ. Instrum. 13, C05005 (2018).
  19. S. J. Alloo, D. M. Paganin, K. S. Morgan, M. J. Kitchen, A. W. Stevenson, S. C. Mayo, H. T. Li, B. M. Kennedy, A. Maksimenko, J. C. Bowden, and K. M. Pavlov, “Dark-field tomography of an attenuating object using intrinsic x-ray speckle-tracking,” \JournalTitleJ. Med. Imaging 9(3), 031502 (2022).
  20. R. Smith, F. De Marco, L. Broche, M.-C. Zdora, N. W. Phillips, R. Boardman, and P. Thibault, “X-ray directional dark-field imaging using Unified Modulated Pattern Analysis,” \JournalTitlePLoS ONE 17(8), e0273315 (2022).
  21. F. A. Vittoria, M. Endrizzi, P. C. Diemoz, A. Zamir, U. H. Wagner, C. Rau, I. K. Robinson, and A. Olivo, “X-ray absorption, phase and dark-field tomography through a beam tracking approach,” \JournalTitleSci. Rep. 5, 16318 (2015).
  22. M. Endrizzi, P. C. Diemoz, T. P. Millard, J. Louise Jones, R. D. Speller, I. K. Robinson, and A. Olivo, “Hard X-ray dark-field imaging with incoherent sample illumination,” \JournalTitleAppl. Phys. Lett. 104(2), 024106 (2014).
  23. A. Doherty, S. Savvidis, C. Navarrete-León, M. F. M. Gerli, A. Olivo, and M. Endrizzi, “Edge-Illumination X-Ray Dark-Field Tomography,” \JournalTitlePhys. Rev. Appl. 19(5), 054042 (2023).
  24. D. M. Paganin and K. S. Morgan, “X-ray Fokker–Planck equation for paraxial imaging,” \JournalTitleSci. Rep. 9, 17537 (2019).
  25. T. E. Gureyev, D. M. Paganin, B. Arhatari, S. T. Taba, S. Lewis, P. C. Brennan, and H. M. Quiney, “Dark-field signal extraction in propagation-based phase-contrast imaging,” \JournalTitlePhys. Med. Biol. 65(21), 215029 (2020).
  26. A. Aminzadeh, B. D. Arhatari, A. Maksimenko, C. J. Hall, D. Hausermann, A. G. Peele, J. Fox, B. Kumar, Z. Prodanovic, M. Dimmock, D. Lockie, K. M. Pavlov, Y. I. Nesterets, D. Thompson, S. C. Mayo, D. Paganin, S. T. Taba, S. Lewis, P. C. Brennan, H. M. Quiney, and T. E. Gureyev, “Imaging breast microcalcifications using dark-field signal in propagation-based phase-contrast tomography,” \JournalTitleIEEE Trans. Med. Imaging 41(11), 2980–2990 (2022).
  27. T. A. Leatham, D. M. Paganin, and K. S. Morgan, “X-ray dark-field and phase retrieval without optics, via the Fokker-Planck equation,” \JournalTitleIEEE Trans. Med. Imaging 42(6), 1681–1695 (2023).
  28. J. N. Ahlers, K. M. Pavlov, M. J. Kitchen, and K. S. Morgan, “X-ray dark-field via spectral propagation-based imaging,” \JournalTitlearXiv preprint arXiv:2309.15874 (2023).
  29. A. Snigirev, I. Snigireva, V. Kohn, S. Kuznetsov, and I. Schelokov, “On the possibilities of x-ray phase contrast microimaging by coherent high-energy synchrotron radiation,” \JournalTitleRev. Sci. Instrum. 66(12), 5486–5492 (1995).
  30. P. Cloetens, R. Barrett, J. Baruchel, J. Guigay, and M. Schlenker, “Phase objects in synchrotron radiation hard x-ray imaging,” \JournalTitleJ. Phys. D: Appl. Phys 29(1), 133–146 (1996).
  31. S. W. Wilkins, T. E. Gureyev, D. Gao, A. Pogany, and A. W. Stevenson, “Phase-contrast imaging using polychromatic hard x-rays,” \JournalTitleNature 384(6607), 335–338 (1996).
  32. M. R. Teague, “Deterministic phase retrieval: a Green’s function solution,” \JournalTitleJ. Opt. Soc. Am. 73, 1434–1441 (1983).
  33. D. Paganin, S. C. Mayo, T. E. Gureyev, P. R. Miller, and S. W. Wilkins, “Simultaneous phase and amplitude extraction from a single defocused image of a homogeneous object,” \JournalTitleJ. Microsc. 206, 33–40 (2002).
  34. T. Weitkamp, D. Hass, D. Wegrzynek, and A. Rack, “ANKAphase: software for single-distance phase retrieval from inline X-ray phase-contrast radiographs,” \JournalTitleJ. Synchrotron Rad. 18(4), 617–629 (2011).
  35. T. E. Gureyev, Y. Nesterets, D. Ternovski, D. Thompson, S. W. Wilkins, A. W. Stevenson, A. Sakellariou, and J. A. Taylor, “Toolbox for advanced x-ray image processing,” Proc. SPIE 8141, 841410B (2011).
  36. M. A. Beltran, D. M. Paganin, K. Uesugi, and M. J. Kitchen, “2D and 3D X-ray phase retrieval of multi-material objects using a single defocus distance,” \JournalTitleOpt. Express 18(7), 6423–6436 (2010).
  37. M. A. Beltran, D. M. Paganin, and D. Pelliccia, “Phase-and-amplitude recovery from a single phase contrast image using partially spatially coherent radiation,” \JournalTitleJ. Opt. 20(5), 055605 (2018).
  38. K. S. Morgan and D. M. Paganin, “Applying the Fokker–Planck equation to grating-based x-ray phase and dark-field imaging,” \JournalTitleSci. Rep. 9, 17465 (2019).
  39. D. M. Paganin, D. Pelliccia, and K. S. Morgan, “Paraxial diffusion-field retrieval,” \JournalTitlePhys. Rev. A 108(1), 013517 (2023).
  40. Ya. I. Nesterets, “On the origins of decoherence and extinction contrast in phase-contrast imaging,” \JournalTitleOpt. Commun. 281, 533–542 (2008).
  41. D. M. Paganin, M. Sales, P. M. Kadletz, W. Kockelmann, M. A. Beltran, H. F. Poulsen, and S. Schmidt, “Revisiting Neutron Propagation-Based Phase-Contrast Imaging and Tomography: Use of Phase Retrieval to Amplify the Effective Degree of Brilliance,” \JournalTitlePhys. Rev. Appl. 19(3), 034005 (2023).
  42. D. M. Paganin, V. Favre-Nicolin, A. Mirone, A. Rack, J. Villanova, M. P. Olbinado, V. Fernandez, J. C. da Silva, and D. Pelliccia, “Boosting spatial resolution by incorporating periodic boundary conditions into single-distance hard-x-ray phase retrieval,” \JournalTitleJ. Opt. 22(11), 115607 (2020).
  43. J. A. Pollock, K. S. Morgan, L. C. P. Croton, M. K. Croughan, G. Ruben, N. Yagi, H. Sekiguchi, and M. J. Kitchen, “Precise phase retrieval for propagation-based images using discrete mathematics,” \JournalTitleSci. Rep. 12, 18469 (2022).
  44. S. K. Lynch, V. Pai, J. Auxier, A. F. Stein, E. E. Bennett, C. K. Kemble, X. Xiao, W. Lee, N. Y. Morgan, and H. H. Wen, “Interpretation of dark-field contrast and particle size selectivity in grating interferometers,” \JournalTitleAppl. Opt. 50(22), 4310–4319 (2011).
  45. C. Hall, D. Hausermann, A. Maksimneko, A. Astolfo, K. Siu, J. Pearson, and A. Stevenson, “Detectors for the Imaging and Medical Beam Line at the Australian Synchrotron,” \JournalTitleJ. Instrum. 8, C06011 (2013).
  46. S. van der Walt, J. L. Schönberger, J. Nunez-Iglesias, F. Boulogne, J. D. Warner, N. Yager, E. Gouillart, T. Yu, and the scikit-image contributors, “scikit-image: image processing in Python,” (2023). https://scikit-image.org/docs/stable/api/skimage.registration.html.
  47. B. A. Dowd, G. H. Campbell, R. B. Marr, V. V. Nagarkar, S. V. Tipnis, L. Axe, and D. Peter Siddons, “Developments in synchrotron x-ray computed microtomography at the National Synchrotron Light Source,” Proc. SPIE 3772, 224-236 (1999).
  48. N. Bevins, J. Zambelli, Z. Qi, and G. Chen, “X-ray dark-field computed tomography using a grating interferometer setup,” Proc. SPIE 7622, 76220P (2010).
  49. J. G. Brankov, M. N. Wernick, Y. Yang, J. Li, C. Muehleman, Z. Zhong, and M. A. Anastasio, “A computed tomography implementation of multiple-image radiography,” \JournalTitleMed. Phys. 33(2), 278–289 (2006).
  50. I. Zanette, T. Weitkamp, G. Le Duc, and F. Pfeiffer, “X-ray grating-based phase tomography for 3D histology,” \JournalTitleRSC Adv. 3(43), 19816–19819 (2013).
  51. R. P. Carnibella, A. Fouras, and M. J. Kitchen, “Single-exposure dual-energy-subtraction X-ray imaging using a synchrotron source,” \JournalTitleJ. Synchrotron Radiat. 19(6), 954–959 (2012).
  52. F. García-Moreno, P. H. Kamm, T. R. Neu, F. Bülk, R. Mokso, C. M. Schlepütz, M. Stampanoni, and J. Banhart, “Using X-ray tomoscopy to explore the dynamics of foaming metal,” \JournalTitleNat. Commun. 10, 3762 (2019).
  53. F. García-Moreno, P. H. Kamm, T. R. Neu, F. Bülk, M. A. Noack, M. Wegener, N. von der Eltz, C. M. Schlepütz, M. Stampanoni, and J. Banhart, “Tomoscopy: Time-Resolved Tomography for Dynamic Processes in Materials,” \JournalTitleAdv. Mater. 33(45), 2104659 (2021).
  54. P. K. Poola and R. John, “Label-free nanoscale characterization of red blood cell structure and dynamics using single-shot transport of intensity equation,” \JournalTitleJ. Biomed. Opt 22(10), 106001 (2017).
  55. A. C. Y. Liu, D. M. Paganin, L. Bourgeois, and P. N. H. Nakashima, “Projected thickness reconstruction from a single defocussed transmission electron microscope image of an amorphous object,” \JournalTitleUltramicroscopy 111(8), 959–968 (2011).
  56. T. H. Jensen, M. Bech, O. Bunk, T. Donath, C. David, R. Feidenhans’l, and F. Pfeiffer, “Directional x-ray dark-field imaging,” \JournalTitlePhys. Med. Biol. 55(12), 3317–3323 (2010).
  57. T. H. Jensen, M. Bech, I. Zanette, T. Weitkamp, C. David, H. Deyhle, S. Rutishauser, E. Reznikova, J. Mohr, R. Feidenhans’l, and F. Pfeiffer, “Directional x-ray dark-field imaging of strongly ordered systems,” \JournalTitlePhys. Rev. B 82, 214103 (2010).
  58. M. L. Siew, A. B. Te Pas, M. J. Wallace, M. J. Kitchen, R. A. Lewis, A. Fouras, C. J. Morley, P. G. Davis, N. Yagi, K. Uesugi, and S. B. Hooper, “Positive end-expiratory pressure enhances development of a functional residual capacity in preterm rabbits ventilated from birth,” \JournalTitleJ. Appl. Physiol. 106(5), 1487–1493 (2009).
  59. C. S. Stahr, C. R. Samarage, M. Donnelley, N. Farrow, K. S. Morgan, R. C. Zosky, G. Boucher, K. K. W. Siu, M. A. Mall, D. W. Parsons, S. Dubsky, and A. Fouras, “Quantification of heterogeneity in lung disease with image-based pulmonary function testing,” \JournalTitleSci. Rep. 6, 29438 (2016).
  60. R. Gradl, M. Dierolf, B. Günther, L. Hehn, W. Möller, D. Kutschke, L. Yang, M. Donnelley, R. Murrie, A. Erl, T. Stoeger, B. Gleich, K. Achterhold, O. Schmid, F. Pfeiffer, and K. S. Morgan, “In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source,” \JournalTitleSci. Rep. 8, 6788 (2018).
  61. K. S. Morgan, M. Donnelley, N. Farrow, N. Fouras, A. Yagi, Y. Suzuki, A. Takeuchi, K. Uesugi, R. C. Bocuher, K. K. W. Siu, and D. W. Parsons, “In Vivo X-ray Imaging Reveals Improved Airway Surface Hydration after a Therapy Designed for Cystic Fibrosis,” \JournalTitleAm. J. Respir. Crit. Care Med. 190, 469–472 (2014).
  62. M. Frank, F. T. Gassert, T. Urban, K. Willer, W. Noichl, R. Schick, M. Schultheiss, M. Viermetz, B. Gleich, F. De Marco, J. Herzen, T. Koehler, K. J. Engel, B. Renger, F. G. Gassert, A. Sauter, A. A. Fingerle, B. Haller, M. R. Makowski, D. Pfeiffer, and F. Pfeiffer, “Dark-field chest X-ray imaging for the assessment of COVID-19-pneumonia,” \JournalTitleCommun. Med. 2, 147 (2022).
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