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Fundamental Bound on Epidemic Overshoot in the SIR Model

Published 3 Mar 2023 in q-bio.PE, physics.bio-ph, and physics.soc-ph | (2303.01650v5)

Abstract: We derive an exact upper bound on the epidemic overshoot for the Kermack-McKendrick SIR model. This maximal overshoot value of 0.2984... occurs at R0<sup>∗R_0<sup>* = 2.151... . In considering the utility of the notion of overshoot, a rudimentary analysis of data from the first wave of the COVID-19 pandemic in Manaus, Brazil highlights the public health hazard posed by overshoot for epidemics with R0R_0 near 2. Using the general analysis framework presented within, we then consider more complex SIR models that incorporate vaccination.

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