Tomographic Imaging by a Si/CdTe Compton Camera for In-111 and I-131 Radionuclides

Abstract: Tomographic imaging with radionuclides commonly used in nuclear medicine, such as $^{111}$In (171 and 245 keV) and $^{131}$I (364 keV), is in high demand for medical applications and small animal imaging. The Si/CdTe Compton camera with its high angular and high energy resolutions is an especially promising detector to extend the energy coverage for imaging to the range that covers gamma-ray emitted from these radionuclides. Here, we take the first steps towards short-distance imaging by conducting experiments using three-dimensional phantoms composed of multiple sphere-like solutions of $^{111}$In and $^{131}$I with a diameter of 2.7 mm, placed at a distance of 41 mm. Using simple back-projection methods, the positions of the sources are reproduced with a spatial resolution of 11.5 mm and 9.0 mm (FWHM) for $^{111}$In and $^{131}$I, respectively. We found that a LM-MLEM method gives a better resolution of 4.0 mm and 2.7 mm (FWHM). We resolve source positions of a tetrahedron structure with a source-to-source separation of 28 mm. These findings demonstrate that Compton Cameras have the potential of close-distance imaging of radioisotopes distributions in the energy range below 400 keV.