Pixelated Chemical Displays

Abstract: An increasing number of applications in biology, chemistry, and material sciences require fluid manipulation beyond what is possible with current automated pipette handlers, such as gradient generation, interface reactions, reagent streaming, and reconfigurability. In this article, we introduce the pixelated chemical display (PCD), a new scalable strategy to highly parallel, reconfigurable liquid handling on open surfaces. Microfluidic pixels are created when a fluid stream injected above a surface is confined by neighboring identical fluid streams, forming a repeatable flow unit that can be used to tesselate a surface. PCDs generating up to 144 pixels are fabricated and used to project chemical moving pictures made of several reagents over both immersed and dry surfaces, without any physical barrier or wall. Overall, this article sets the foundation for massively parallel surface processing using continuous flow streams and showcases new possibilities in both wet and dry surface patterning and roll-to-roll processes.