Antimicrobial Peptide Prediction Using Ensemble Learning Algorithm

Abstract: Recently, Antimicrobial peptides (AMPs) have been an area of interest in the researches, as the first line of defense against the bacteria. They are raising attention as an efficient way of fighting multidrug resistance. Discovering and identification of AMPs in the wet labs are challenging, expensive, and time-consuming. Therefore, using computational methods for AMP predictions have grown attention as they are more efficient approaches. In this paper, we developed a promising ensemble learning algorithm that integrates well-known learning models to predict AMPs. First, we extracted the optimal features from the physicochemical, evolutionary, and secondary structure properties of the peptide sequences. Our ensemble algorithm then trains the data using conventional algorithms. Finally, the proposed ensemble algorithm has improved the performance of the prediction by about 10% comparing to the traditional learning algorithms