Abstract: This paper considers flag-transitive $4$-(q+1,k,λ) designs with λ≥5 and $q+1>k>4$. Let the automorphism group of a design D be a simple group G=PSL(2,q). Depend on the fact that the setwise stabilizer GB​ must be one of twelve kinds of subgroups, up to isomorphism we get the following two results. (i) If 10≥λ≥5, then except (G,Gx​,GB​,k,λ)=(PSL(2,761),E761​⋊C380​,S4​,24,7) or (PSL(2,512),E512​⋊C511​,D18​,18,8) undecided, D is a $4$-(24,8,5), $4$-(9,8,5), $4$-(8,6,6), $4$-(10,9,6), $4$-(9,6,10), $4$-(9,7,10), $4$-(12,11,8) or $4$-(14,13,10) design with GB​=D8​, E8​⋊C7​, D6​, E9​⋊C4​, PSL(2,2), D14​, E11​⋊C5​ or E13​⋊C6​ respectively. (ii) If $\lambda>10$, GB​=A4​, S4​, A5​, PGL(2,q0​)($g>1$ even) or PSL(2,q0​), where q0​<sup>g=q, then there is no such design.