Gene Ontology (GO) Prediction using Machine Learning Methods

Abstract: We applied machine learning to predict whether a gene is involved in axon regeneration. We extracted 31 features from different databases and trained five machine learning models. Our optimal model, a Random Forest Classifier with 50 submodels, yielded a test score of 85.71%, which is 4.1% higher than the baseline score. We concluded that our models have some predictive capability. Similar methodology and features could be applied to predict other Gene Ontology (GO) terms.