Towards a scientific blockchain framework for reproducible data analysis

Abstract: Publishing reproducible analyses is a long-standing and widespread challenge for the scientific community, funding bodies and publishers. Although a definitive solution is still elusive, the problem is recognized to affect all disciplines and lead to a critical system inefficiency. Here, we propose a blockchain-based approach to enhance scientific reproducibility, with a focus on life science studies and precision medicine. While the interest of encoding permanently into an immutable ledger all the study key information-including endpoints, data and metadata, protocols, analytical methods and all findings-has been already highlighted, here we apply the blockchain approach to solve the issue of rewarding time and expertise of scientists that commit to verify reproducibility. Our mechanism builds a trustless ecosystem of researchers, funding bodies and publishers cooperating to guarantee digital and permanent access to information and reproducible results. As a natural byproduct, a procedure to quantify scientists' and institutions' reputation for ranking purposes is obtained.