The integrated model of cAMP-dependent DNA expression reveals an inverse relationship between cancer and neurodegeneration

Abstract: The model for cAMP-dependent synaptic plasticity relates the characterization of a noradrenaline-stimulated adenylyl cyclase with DNA unzipping. Specific proteins condition cAMP insertion in specific sites of the DNA structure to direct cellular and synaptic differentiation in brain tissues, also providing coding. Metabolic-dependent ATP binding of Mg2+, could control feedback by inactivating AC dependent formation of cAMP. The level of cAMP and cGMP, which could be assayed in red cells and cerebrospinal fluid, allows a clinical lab diagnostic improvement. Also, provides a relationship of best fitting to cAMP control by binding to DNA. The cAMP level allows the prediction of an inverse relationship between neurodegeneration and cancer. The latter, could be characterized by uncontrolled proliferation, whereas metabolic dominance by stress over a long period of time, may deplete cerebral cAMP.