MetaScope - Fast and accurate identification of microbes in metagenomic sequencing data

Abstract: MetaScope is a fast and accurate tool for analyzing (host-associated) metagenome datasets. Sequence alignment of reads against the host genome (if requested) and against microbial Genbank is performed using a new DNA aligner called SASS. The output of SASS is processed so as to assign all microbial reads to taxa and genes, using a new weighted version of the LCA algorithm. MetaScope is the winner of the 2013 DTRA software challenge entitled "Identify Organisms from a Stream of DNA Sequences".