An argument against the realistic interpretation of the wave function

Abstract: Testable predictions of quantum mechanics are invariant under time reversal. But the change of the quantum state in time is not so, neither in the collapse nor in the no-collapse interpretations of the theory. This fact challenges the realistic interpretation of the quantum state. On the other hand, this fact follows easily if we interpret the quantum state as a mere calculation device, bookkeeping past real quantum events. The same conclusion follows from the analysis of the meaning of the wave function in the semiclassical regime.