Abstract: Quantum-correlated ψ(3770)→DDˉ decays collected by the CLEO-c experiment are used to perform a first measurement of F+<sup>4π, the fractional CP-even content of the self-conjugate decay D→π<sup>+π<sup>−π<sup>+π<sup>−, obtaining a value of 0.737±0.028. An important input to the measurement comes from the use of D→K<sup>0</sup>Sπ<sup>+π<sup>− and D→K<sup>0</sup>Lπ<sup>+π<sup>− decays to tag the signal mode. This same technique is applied to the channels D→π<sup>+π<sup>−π<sup>0 and D→K<sup>+K<sup>−π<sup>0, yielding F+<sup>πππ<sup>0</sup></sup>=1.014±0.045±0.022 and F+<sup>KKπ<sup>0</sup></sup>=0.734±0.106±0.054, where the first uncertainty is statistical and the second systematic. These measurements are consistent with those of an earlier analysis, based on CP-eigenstate tags, and can be combined to give values of F+<sup>πππ<sup>0</sup></sup>=0.973±0.017 and F+<sup>KKπ<sup>0</sup></sup>=0.732±0.055. The results will enable the three modes to be included in a model-independent manner in measurements of the unitarity triangle angle γ using B<sup>∓</sup>→DK<sup>∓ decays, and in time-dependent studies of CP violation and mixing in the DDˉ system.