Directional locking in deterministic lateral displacement microfluidic separation systems

Abstract: We analyze the trajectory of suspended spherical particles moving through a square array of obstacles, in the deterministic limit and at zero Reynolds number. We show that, in the dilute approximation of widely separated obstacles, the average motion of the particles is equivalent to the trajectory followed by a point particle moving through an array of obstacles with an effective radius. The effective radius accounts for the hydrodynamic as well as short-range repulsive non-hydrodynamic interactions between the suspended particles and the obstacles and is equal to the critical offset at which particle trajectories become irreversible. Using this equivalent system we demonstrate the presence of directional locking in the trajectory of the particles and derive an inequality that accurately describes the Devil's staircase type of structure observed in the migration angle as a function of the forcing direction. Finally, we use these results to determine the optimum resolution in the fractionation of binary mixtures using deterministic lateral displacement separation microfluidic systems.