Twin Prime Conjecture
Determine whether there exist infinitely many twin primes, that is, infinitely many pairs of primes (p, p+2).
References
If there are infinitely many twin primes (an open question), then this program is circle-free.
— Did Turing prove the undecidability of the halting problem?
(2407.00680 - Hamkins et al., 30 Jun 2024) in Subsection "Circle-freeness", Section "The circle-free problem"