Selection-aware inference after preliminary feature screening

Develop sample-splitting or other selection-aware procedures that account theoretically for preliminary feature screening in high-dimensional sparse support vector machine applications.

Background

The breast cancer analysis first screens thousands of genes and then applies the proposed inferential procedure to the selected features. Because this screening is data-dependent, the reported post-screening p-values are only illustrative and do not provide unconditional genome-wide error control. The paper identifies selection-aware procedures as an unresolved requirement for a cleaner end-to-end inferential framework.

References

Several directions remain open. First, the present theory is restricted to balanced, linearly separable data; extending it to class-imbalanced designs \citep{Loffredo2024RestoringBalance} or to the nonseparable perceptron regime \citep{Franz2019CriticalJammed} is a natural next step. Second, the theoretical framework is based on a replica-symmetric characterization and does not provide a rigorous proof of the RS ansatz or its stability; establishing such results, or identifying conditions under which the RS solution can be justified rigorously, is an important theoretical problem. Third, the framework assumes a Gaussian-mixture model for the class-conditional distributions, and extending the theory to broader distributional classes would increase its applicability. Fourth, the current analysis is restricted to the $L_1$ penalty; extending the proportional-asymptotic theory to nonconvex penalties such as SCAD \citep{fan2001variable} or MCP could combine reduced regularization bias with formal inferential guarantees. Fifth, a theoretically justified, data-driven procedure for selecting the tuning parameter $\lambda$ remains an important problem. Finally, developing sample-splitting or other selection-aware procedures for the preliminary screening step in high-dimensional applications would provide a cleaner end-to-end inferential framework.

— High-Dimensional Statistical Inference for Sparse Support Vector Machines  (2610.08345 - Zeng et al., 6 Oct 2026) in Conclusion, Section 5