Recognizability of the four-sphere
Determine whether the four-sphere is recognizable among closed four-manifolds; that is, determine whether an algorithm can decide from a triangulation of a closed four-manifold whether it is homeomorphic to $S^4$.
References
It is a major open question whether $S4$ is recognizable; see, for example, Problem~4.53 in the K3 problem list .
— Small undecidable groups and unrecognizable 4-manifolds
(2609.10461 - Kegel et al., 9 Sep 2026) in Section 1, subsection “Topology”