Minimum-size DAG or network realization
Determine the computational complexity of finding a directed acyclic graph or phylogenetic network that realizes a given relation R with the minimum number of vertices.
References
Determining the computational complexity of finding a DAG or network realizing $R$ with the minimum number of vertices thus remains an open problem.
— Inferring DAGs and Phylogenetic Networks from Least Common Ancestors
(2511.07965 - Lindeberg et al., 11 Nov 2025) in Section 8, Discussion and Outlook, paragraph “Underlying Optimization Problems”