Minimum-hybrid realization
Determine the computational complexity of finding a directed acyclic graph or phylogenetic network that realizes a relation R while minimizing the number of hybrid vertices globally or within each biconnected component.
References
We therefore also pose the problem of determining the computational complexity of finding a DAG or network that realizes $R$ with as few hybrids as possible, either globally or per biconnected component.
— Inferring DAGs and Phylogenetic Networks from Least Common Ancestors
(2511.07965 - Lindeberg et al., 11 Nov 2025) in Section 8, Discussion and Outlook, paragraph “Underlying Optimization Problems”