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Mechanism of hemoglycin replication or self-assembly

Ascertain the physical and chemical mechanism by which hemoglycin polymers undergo replication or self-assembly that would drive growth of the diamond 2H rod lattice in space, consistent with observations such as the chiral 480 nm absorption signature.

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Background

The authors propose that hemoglycin’s exceptional space-filling efficiency could confer a selection advantage via a form of self-assembly or replication, enabling the lattice to intercept and accrete precursor materials in molecular clouds.

Evidence related to chiral optical activity near 480 nm suggests a route to self-organization, but the specific replication/self-assembly mechanism is not established, and the authors explicitly note this knowledge gap.

References

Implicit in this mechanism was a form of replication, or self-assembly, clues for which have been seen in relation to the chiral 480nm absorption of hemoglycin (McGeoch et al 2022). However, the mechanism of this replication remains unknown.

Space-filling efficiency and optical properties of hemoglycin (2507.10612 - McGeoch et al., 13 Jul 2025) in Discussion (main text)