Mechanism of hemoglycin replication or self-assembly

Ascertain the physical and chemical mechanism by which hemoglycin polymers undergo replication or self-assembly that would drive growth of the diamond 2H rod lattice in space, consistent with observations such as the chiral 480 nm absorption signature.

Background

The authors propose that hemoglycin’s exceptional space-filling efficiency could confer a selection advantage via a form of self-assembly or replication, enabling the lattice to intercept and accrete precursor materials in molecular clouds.

Evidence related to chiral optical activity near 480 nm suggests a route to self-organization, but the specific replication/self-assembly mechanism is not established, and the authors explicitly note this knowledge gap.

References

Implicit in this mechanism was a form of replication, or self-assembly, clues for which have been seen in relation to the chiral 480nm absorption of hemoglycin (McGeoch et al 2022). However, the mechanism of this replication remains unknown.

Space-filling efficiency and optical properties of hemoglycin (2507.10612 - McGeoch et al., 13 Jul 2025) in Discussion (main text)