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Ubiquitous 3'UTR for transcript stability and expression

Identify a ubiquitous 3' untranslated region (3'UTR) that stabilizes transcripts and enhances transgene expression across tissues and developmental stages in tardigrades.

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Background

3'UTR selection can critically influence mRNA stability and translation efficiency, yet no standard ubiquitous 3'UTR has been identified for tardigrades.

Resolving this will improve transgene robustness and facilitate reproducible neural imaging across life stages.

References

Identifying a ubiquitous 3'UTR that stabilizes transcripts and enhances transgene expression across tissues and developmental stages remains equally unknown.

— The tardigrade as an emerging model organism for systems neuroscience (2501.06606 - Lyons et al., 11 Jan 2025) in Section II. Call to Action: Molecular biology, genomics, and genetic engineering tools, Promoter optimization