Four-dimensional Hessian conjecture
Determine whether every polynomial potential in four variables with nonzero constant Hessian determinant has a polynomially invertible gradient mapping, thereby resolving the remaining four-dimensional case of the Hessian conjecture.
References
Together with the preceding positive results, this leaves the Hessian conjecture open only in dimension four; similarly, the Jacobian conjecture is open only in dimension two, and the four-dimensional Hessian conjecture implies the two-dimensional Jacobian conjecture.
— On the Hessian Conjecture in Lorentzian Signature: Constant Pivots and Hesse Systems
(2608.19112 - Liu, 19 Aug 2026) in Section 1, subsection “Historical Background and Overview”